The rising crisis of illicit fentanyl use, overdose, and potential therapeutic strategies Translational Psychiatry
Fentanyl has been shown to exert its analgesic and lethal effects through different receptor populations in the CNS. It is eliminated from cerebrospinal fluid at approximately the same rate as morphine70,71. Acute naloxone administration antagonizes fentanyl-induced analgesia more than fentanyl-induced lethality. Β-funaltrexamine was shown to inhibit both fentanyl-induced analgesia and lethality71. Overdose-related concentrations of fentanyl …